Ti consigliamo la presentazione del ns. specialista Andrea Pigozzo:
"Microcalorimetry of Nanoparticles: a ground-breaking approach for drug delivery platforms design" - Mercoledì 21 Settembre 2016 ore 12:40
Abstract: Microcalorimetry is the universal detector of heat. Since heat is generated or absorbed in every chemical process, microcalorimetry is a super-versatile technique for characterize interactions. Of all the techniques that are currently available to measure binding, isotherm titration calorimetry (ITC) is the only one capable of measuring not only the magnitude of the binding affinity but also the magnitude of the two thermodynamic terms that define it (Enthalpy and Entropy).
Nanoparticles offer several advantages as drug delivery systems. Efficient nanoparticles formulations should combine a number of different properties such as efficient drug loading, controlled drug release, stealthiness and drug targeting. This can be achieved by the design of nanoparticles bearing different functionalities at their surface.
Thanks to the universality of the technique, ITC provides a widely applicable method for monitoring nanoparticle drug delivery systems development in a label-free environment and so it represent a powerful technology for use in drug discovery, drug delivery, pharmaceutical formulations as well as the study of NPs interaction with living system. Applications of this innovative approach will be presented.